Polynucleotides v’s Profhilo? Polynucleotides are biostimulators that help repair and refresh the skin at a cellular level. They are great for texture problems, under-eye issues, sun damage, and scars.
Profhilo is a skin booster made with hyaluronic acid. It deeply hydrates the skin and helps rebuild collagen and elastin. This improves skin laxity for a firmer and plumper appearance.
Treatment protocols differ: Polynucleotides typically require 3 sessions, 2 weeks apart. Profhilo usually involves 2 sessions spaced 4 weeks apart.
Many patients combine the two for maximum hydration + regeneration.
The Rise of Advanced Skin Boosters
In Wigan and Greater Manchester, more patients are turning to injectable treatments that go beyond smoothing fine lines. The newest injectable treatments work beneath the skin. They improve skin quality, hydration, and bio-remodeling. They do this without the bulk of a dermal filler.
Two leading options stand out: polynucleotides and Profhilo. While both target skin ageing, and improve skin tone, they work in very different ways. This guide will explain the differences, who suits what, and why combining them may give the best results.
What Are Polynucleotides?
Polynucleotides are regenerative biostimulators. Made from purified fish DNA fragments, they stimulate fibroblasts, boost collagen and elastin, and reduce inflammation.
Key Benefits
- Improve texture and tone
- Treat under-eye hollows and dark circles (an area Profhilo isn’t suitable for)
- Support recovery from sun damage or acne scarring
- Strengthen fragile, thin, or crepey skin
Results take longer to appear than with a traditional filler, but they deliver deep structural improvements that last.
What Is Profhilo?
Profhilo is often described as an “injectable moisturiser.” It contains ultra-pure hyaluronic acid stabilised with patented NAHYCO® technology.
With just five injection sites on each side of the face, the skin booster spreads evenly under the skin. It helps to stimulate collagen and elastin while also hydrating the skin.
Treatment Benefits
- Deeply hydrates and plumps
- Smooths fine lines and crepiness
- Improves skin laxity across the face, neck, and décolletage
- Leaves skin with an improved tone and glow
Unlike a dermal filler, Profhilo does not add volume, it remodels and refreshes from within.
Polynucleotides vs Profhilo: Comparison Chart
| Feature | Polynucleotides (PN/PDRN) | Profhilo (Face/Neck) | Profhilo Body |
|---|---|---|---|
| Core Action | Cellular repair & regeneration | Hydration + bio remodelling | Hydration + bio remodelling |
| Best For | Under-eye, texture, scars, sun damage | Hydration, glow, skin laxity | Crepey skin on arms, abdomen, knees |
| Sessions | 3 sessions, 2 weeks apart | 2 sessions, 4 weeks apart | 2–3 sessions, 4 weeks apart |
| Duration | Gradual, long-lasting repair | Fast glow, lasts ~6 months | 6–9 months typical |
| Session Time | 45 minutes | 45 minutes | 45 minutes |
| Downtime | Mild redness/swelling | Small bumps at injection sites (24h) | Mild redness/swelling |
| Price (SF Aesthetics Wigan) | £275 per session | From £275 per session | £495 per session |
Can I do Profhilo and Polynucleotides together?
Yes — they complement each other perfectly.
Is anything better than Profhilo?
For hydration, Profhilo excels. For under-eye and repair, Polynucleotides may be more effective.
What is better than Polynucleotides for the face?
For volume: a dermal filler. For hydration: Profhilo. For regeneration: Polynucleotides.
Is Polynucleotide better than Profhilo?
It depends on your goals: regeneration vs hydration. Many patients combine both.
Do Polynucleotides really work?
Yes, studies show they stimulate fibroblasts, boost collagen, and improve skin quality.
What is the best skin booster in the world?
There isn’t one single best. Profhilo and Polynucleotides are both leading options, excelling in different areas of skin ageing.
